ESP Biography

MATTHEW LLOYD, 1st year Interdisciplinary Bioscience DTP student

Major: Interdisciplinary Bioscience

College/Employer: Oxford

Year of Graduation: G

Picture of Matthew Lloyd

Brief Biographical Sketch:

I am working in a partnership between the department of Physiology, Anatomy and Genetics and Novo Nordisk, the leading pharmaceutical company in the field of diabetes treatment. My current research interest is in the effects of glycogen accumulation on beta-cells in diabetes. This is an overlooked aspect of the disease, which may cause major metabolic and physiological changes in the pancreatic islets leading to a loss of insulin secretion. Better understanding these processes could lead to treatments to restore endogenous insulin secretion in diabetics who are reliant on insulin therapy.

Past Classes

  (Look at the class archive for more.)

Diabetes: how to fight an epidemic in Splash Hilary 2019
Diabetes presents a growing global health crisis. Over 400 million people worldwide are diabetic, and diabetes currently costs the NHS £14 billion per year. With these numbers projected to reach over 600 million and £17 billion by 2035, there is an urgent need to stop costs spiralling before healthcare systems become overwhelmed by the strain. This lesson will provide an introduction to the different types of diabetes, their underlying biology, the treatments available, and why the NHS diabetes budget is spent so inefficiently. You’ll then work in teams to design a new public health strategy aimed at reducing type II diabetes incidence and improving treatment outcomes in a cost-effective manner. Can you make society healthier?

Circadian Rhythms and Sleep: the dangers of disrupting our body clocks and what to do about it in Splash Hilary 2018
What's better than curing diseases? Preventing them in the first place! Improving our understanding of circadian rhythms could help us prevent a wide range of diseases. Our internal body clock drives daily cycles in many physiological processes and keeps our behaviours synchronised with the outside world. Sleep is the most obviously circadian behaviour, and one of the most dangerous to disrupt. Yet many of us are chronically sleep deprived, with serious long-term health implications. In this lesson we’ll explore the workings of the body clock, how this affects sleep, and the perils of poor sleep. Finally, we’ll discuss practical measures to make society sleep well again.

Mitochondria, Disease and Ethics in Splash Hilary 2017
The mitochondrion is well-known as the "powerhouse of the cell", crucial for providing us with the energy we need. Recently this organelle has gained attention for its role in disease, and its treatment using mitochondrial replacement therapy (MRT) to produce "three-parent babies". We'll examine the function of mitochondria, how they can cause disease, and the possible methods and ethical implications of MRT.

How do cells talk to each other? in Splash! Hilary 2016
Each of us has around 10 trillion cells in our body and they come in 250 different varieties. All of these cells need to work together, coordinating their activities, to enable a whole range of processes from growth to muscle contraction to occur. So how do they communicate? This course will provide an introduction to cell signalling, an exciting area of research in biochemistry and molecular biology.